Enzyme modulators and treatments

Details Enzyme modulators and treatments Enzyme modulators and treatments

C - Chemistry, Metallurgy

07

D

C07D 401/00 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 231/40 (2006.01) C07D 471/04 (2006.01) C12N 9/96 (2006.01) C12N 9/99 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2592118

Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, hyperproliferative diseases, cancer, and diseases characterized by hypervascularization are provided. In a preferred embodiment, modulation of the activation state of p38 kinase protein ab1 kinase protein, bcr-ab1 kinase protein, braf kinase protein, VEGFR kinase protein, or PDGFR kinase protein comprises the step of contacting said kinase protein with the novel compounds.

.La présente invention a trait à de nouveaux composés et à des procédés d'utilisation de ces composés pour le traitement de conditions inflammatoires, de maladies hyperprolifératives, du cancer, et de maladies caractérisées par l'hypervascularisation. Dans un mode de réalisation préféré, la modulation de l'état d'activation de la protéine kinase p38, la protéine kinase ab1, la protéine kinase bcr-ab1, la protéine kinase braf, la protéine kinase VEGFR, ou la protéine kinase PDGFR comporte l'étape de mise en contact de ladite protéine kinase avec les nouveaux composés.

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