Enzyme phosphorylating ser46 of p53

C - Chemistry – Metallurgy – 12 – N

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C12N 9/12 (2006.01) A61K 38/45 (2006.01) C07K 14/47 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2455117

An enzyme phosphorylating the serine residue at the 46-position in the amino acids of p53 is clarified. Further, the controlling mechanism of the apoptosis- inducing ability of p53 is clarified. As a result, a completely novel enzyme is provided. Namely, an enzyme consisting of casein kinase 2 and p53DINP1.

L'invention concerne une enzyme phosphorylant le résidu de sérine en position 46 dans les aminoacides de la protéine p53. L'invention concerne en outre un mécanisme de contrôle de la capacité d'induction d'apoptose de la protéine p53. Ainsi, une enzyme complètement nouvelle est obtenue, à savoir une enzyme comprenant une caséine kinase 2 et une protéine p53DINP1.

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