C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 3/00 (2006.01) C07K 14/535 (2006.01) C07K 14/575 (2006.01) C12N 9/00 (2006.01) C12N 9/24 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2641070
The present invention relates in general to the field of enzyme replacement therapy, and specifically to chimeric proteins including protein hormone- therapeutic protein conjugates and fusion proteins, wherein the protein hormone is selected from a protein hormone which is able to cross the blood brain barrier, for the treatment of lysosomal storage diseases, compositions comprising same and to methods of use thereof.
La présente invention concerne d'une manière générale le domaine de l'enzymothérapie de remplacement et plus spécifiquement des protéines chimériques comprenant des conjugués hormone protéique-protéine thérapeutique et des protéines hybrides, dans lesquels l'hormone protéique est choisie parmi les hormones protéiques capables de traverser la barrière hémato-encéphalique. L'invention concerne également l'utilisation desdites protéines chimériques pour le traitement de maladies lysosomiales, des compositions qui les comprennent et leurs procédés d'utilisation.
Futerman Anthony
Navon Ruth
Osher Etty
Stern Naftali
Zimran Ari
Futerman Anthony
Navon Ruth
Osher Etty
Ramot At Tel-Aviv University Ltd.
Ridout & Maybee Llp
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