Enzymes coated with ionic liquid

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/20 (2006.01) C12N 9/96 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2441430

Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150~C or below. The ionic liquid-coated enzyme according to the present invention remarkably improves enzyme functions, such as enantioselectivity and stability, when the enzyme which may be lipase is coated with an ionic liquid. Further, even in the case of when the ionic liquid-coated enzyme is reused, the enantiomeric excess, enantioselectivity, and activity are not degenerated. The coated enzyme is usable as a catalyst for providing a chiral intermediate required in the synthesis of chiral pesticides, medicines, natural chemicals, and so on.

La présente invention concerne une enzyme enrobée de liquide ionique, dans laquelle le liquide ionique est un sel organique qui se présente sous la forme d'une phase liquide à une température d'environ 150 ·C au maximum. L'enzyme enrobée de liquide ionique selon la présente invention améliore remarquablement les fonctions de l'enzyme, telles que l'énantiosélectivité et la stabilité, lorsque l'enzyme qui peut être une lipase est enrobée d'un liquide ionique. De plus, même dans le cas où l'enzyme enrobée de liquide ionique est réutilisée, l'excès énantiomérique, l'énantiosélectivité et l'activité ne sont pas dégénérés. L'enzyme enrobée est utilisable en tant que catalyseur pour obtenir un intermédiaire chiral nécessaire dans la synthèse de pesticides, de médicaments, de produits chimiques naturels, chiraux, etc.

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