C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12P 19/34 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G06F 17/50 (2006.01)
Patent
CA 2419975
The invention relates to thermostable polymerases that have polymerase activity temperatures in the range from 9~ C up to 113~ C, such as those derived from Pyrolobus fumaria, and to polynucleotides encoding the polymerases In addition, methods of designing new thermostable DNA polymerases and methods of use thereof are also provided. The polymerases have increased activity and stability at increased pH and temperature.
La présente invention concerne des polymérases stables à la chaleur qui présentent des températures de l'activité polymérase situées dans la plage comprise entre 9· C et 113· C, telles que les polymérases dérivées de Pyrolobus fumaria, et les polynucléotides codant les polymérases. Cette invention concerne également des procédés de création de nouvelles polymérases d'ADN stables à la chaleur et des procédés d'utilisation de ces dernières. Les polymérases présentent une activité et une stabilité accrues à la chaleur dans des conditions de pH et de température plus élevées.
Callen Walter
Mathur Eric J.
Short Jay M.
Diversa Corporation
Mbm Intellectual Property Law Llp
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