Eosinophil chemotaxis inhibitor

Details Eosinophil chemotaxis inhibitor Eosinophil chemotaxis inhibitor

A - Human Necessities

61

K

A61K 31/50 (2006.01)

Patent

CA 2132489

Abstract Eosinophil Chemotaxis Inhibitor A composition for inhibiting an eosinophil chemotaxis which comprises a compound of the formula: Image wherein R1 represents a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; either A or B represents a nitrogen atom with the other representing a methine group, or both of them represents a methine group; R2 and R3 independently represent a hydrogen atom or an optionally substituted lower alkyl group, or R2 and R3 taken together with the adjacent -C=C-, may form a 5- to 7-membered ring; X represents a methylene group, an oxygen atom or S(O)p wherein p represents an integer of 0 to 2; Y represents (i) a group of the formula Image wherein R4 and R5 independently represent a hydrogen atom or an optionally substituted lower alkyl group or (ii) a divalent group derived from an optinally substituted 3- to 7-membered homocyclic or heterocyclic ring; R represents a primary to tertiary amino group; m and n independently represent an integer of 0 to 4, or a salt thereof. Said composition is useful for treating a disease related to eosinophil chemotaxis such as allergic rhinits and/or atopic dermatitis and so on.

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