Eosinophil eotaxin receptor

Details Eosinophil eotaxin receptor Eosinophil eotaxin receptor

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 51/08 (2006.01) C07K 14/715 (2006.01) C12N 5/10 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2252850

The eosinophil eotaxin receptor has been isolated, cloned and sequenced. This receptor is a human .beta.-chemokine receptor and has been designated "CC CKR3". The eosinophil eotaxin receptor may be used to screen and identify compounds that bind to the eosinophil eotaxin receptor. Such compounds would be useful in the treatment and prevention of atopic conditions including allergic rhinitis, dermatis, conjunctivitis, and particularly bronchial asthma.

Le récepteur d'éotaxine éosinophile a été isolé, cloné et séquencé. Ledit récepteur est un récepteur .beta.-chémokine humain et a été baptisé "CC CKR3". Le récepteur d'éotaxine éosinophile peut être utilisé pour rechercher et identifier des composés qui se lient avec le récepteur d'éotaxine éosinophile. De tels composés seraient utiles pour la prévention et le traitement des maladies atopiques comme la rhinite allergique, la dermatite, la conjonctivite et, en particulier, l'asthme bronchique.

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