Eosinophil prostaglandin d2 receptor assays

Details Eosinophil prostaglandin d2 receptor assays Eosinophil prostaglandin d2 receptor assays

G - Physics

01

N

G01N 33/88 (2006.01) C07K 14/72 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2454347

The present invention identifies different activities mediated by eosinophil PGD2 receptors and features methods measuring the ability of a compound to modulate such activities. Activities mediated by eosinophil PGD2 receptors include those associated with CRHT2 and those associated with the DP receptor. Activities identified herein as associated with eosinophil CRHT2 include a change in cell morphology, degranulation, and a specific chemokinetic effect. Activities identified herein as associated with the eosinophil DP receptor include resistance to apoptosis.

L'invention concerne l'identification de différentes activités régulées par les récepteurs PGD¿2? éosinophiles ainsi que des procédés de mesure de la capacité d'un composé à moduler ces activités. Les activités régulées par les récepteurs PGD¿2? éosinophiles comprennent celles associées aux CRHT2 et celles associées au récepteur DP. Les activités identifiées comme étant associées aux CRHT2 éosinophiles comprennent la modification de la morphologie cellulaire, la dégranulation et un effet chimiocinétique spécifique. Les activités identifiées comme étant associées aux récepteurs DP éosinophiles comprennent la résistance à l'apoptose.

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