C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/10 (2006.01) A61K 31/535 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2616608
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts. The compounds of the present invention are the compounds of Formula (I).
La présente invention concerne des agonistes sélectifs puissants de la sous-classe EP4 des récepteurs prostaglandine E2, leur utilisation ou une formule les contenant, pour le traitement du glaucome et d~autres conditions apparentées à une pression intraoculaire élevée de l'AEil d'un patient. Cette invention concerne encore l'utilisation des composés de cette invention intervenant dans le modelage osseux et les procédures de remaniement d'ostéoblastes et d~ostéoclastes. Les composés de la présente invention sont des composés de formule (I).
Colucci John
Farand Julie A.
Han Yongxin
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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