Ep4 receptor inhibitors to treat rheumatoid arthritis

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/4178 (2006.01) A61K 31/00 (2006.01) A61K 31/437 (2006.01) A61K 31/64 (2006.01) A61P 29/00 (2006.01) C07D 235/06 (2006.01) C07D 235/08 (2006.01) C07D 235/12 (2006.01) C07D 235/14 (2006.01) C07D 235/30 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 491/04 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2426487

The invention features a method of treating rheumatoid arthritis in a mammal comprising administering an agent that inhibits prostaglandin EP4 receptor (EP4) activity. Also featured is a method of identifying agents that selectively inhibit EP4 activity in vivo.

L'invention concerne une méthode destinée au traitement de la polyarthrite rhumatoïde chez un mammifère, consistant à administrer un agent inhibant l'activité du récepteur EP4 de la prostaglandine. L'invention concerne également une méthode destinée à l'identification d'agents inhibant de façon sélective l'activité du récepteur EP4 in vivo.

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