Epas1 gene transfer to improve cell therapy

Details Epas1 gene transfer to improve cell therapy Epas1 gene transfer to improve cell therapy

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 5/0775 (2010.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2536472

The present invention concerns the use of nucleotide sequences encoding EPAS1, HIF-1.alpha. and HIF-3.alpha. transcription factors and functional analogs for treating coronary and cardiac diseases in mammals. The use of such transcription factors and its analogs is useful in the treatment of disorders that may be treated by cell therapy such as peripheral vascular disease (PVD), neurodegenerative disease including Parkinson's syndrome, muscular dystrophies, stroke, diabetes, hemophilia, wound and others.

L'invention concerne l'utilisation de séquences nucléotidiques codant les facteurs de transcription EPAS1, HIF-1a et HIF-3a ainsi que leurs analogues fonctionnels pour traiter des maladies coronariennes et cardiaques. Ces facteurs de transcription et leurs analogues sont utilisés dans le traitement de troubles qui peuvent être soignés par thérapie cellulaire, notamment la maladie vasculaire périphérique (PVD), les maladies neurodégénératives incluant le syndrome parkinsonien, les dystrophies musculaires, l'accident vasculaire cérébral, le diabète, l'hémophilie, les plaies, etc.

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