Ephrin and eph receptor mediated immune modulation

Details Ephrin and eph receptor mediated immune modulation Ephrin and eph receptor mediated immune modulation

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C12N 9/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2452578

Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration or modulates apoptosis. The method is useful in treating a variety of conditions including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.

L'invention concerne des méthodes et des compositions d'immunomodulation. Les méthodes décrites dans cette invention consistent à moduler un récepteur Ephrin ou Eph, lequel, à son tour, module une réponse immunitaire, en particulier, une réponse des lymphocytes T, module une cellule d'immunoadhérence, module la chimiotaxie et/ou la migration ou module l'apoptose. La méthode susmentionnée permet de traiter une variété d'affections, parmi lesquelles, une maladie auto-immune, une allergie, une réaction du greffon contre l'hôte, un rejet du greffon, et un cancer.

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