Epi-epibatidine derivatives

Details Epi-epibatidine derivatives Epi-epibatidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/08 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 205/18 (2006.01) C07C 205/45 (2006.01) C07D 213/04 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 277/24 (2006.01) C07D 307/40 (2006.01) C07D 333/06 (2006.01)

Patent

CA 2137611

The compounds of the general Formula XVII Image /wherein R stands for lower alkyl, lower alkenyl, lower alkinyl, lower cycloalkyl, aryl, heteroaryl, aryl-lower alkyl or heteroaryl-lower alkyl, whereby said groups may be optionally substituted by one or more lower alkyl, lower alkenyl, lower alkinyl, lower cycloalkyl, aryl, heteroaryl, aryl-lower alkyl, heteroaryl-lower alkyl, hydroxy, lower alkoxy, phenoxy, halogeno, halogeno- -lower alkyl, amino-, mono- or disubstituted amino-, amido and/or sulfonamido substituent(s); and R' represents hydrogen, lower alkyl, lower alkenyl, lower alkinyl, lower cycloalkyl, lower cycloalkenyl, lower cycloalkinyl, aril-lower alkyl, aryl, heteroaryl, halogeno-lower alkyl, hydroxy-lower alkyl or acyl; and pharmaceutically acceptable acid addition salts there- of exhibit a very strong analgesic effect. - 2 - The compounds of the Formula XVII Image are new with the proviso that R is other than 6-chloro- 3-pyridyl, if R' is hydrogen.

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