Epidermal growth factor receptor mutations

Details Epidermal growth factor receptor mutations Epidermal growth factor receptor mutations

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2601936

Mutations of the epidermal growth factor receptor (EGFr), of phosphatidylinositol 3'-kinase ("PI3K"), and of B-Raf are described. Methods of treating tumors containing mutated EGFr with human monoclonal antibodies against EGFr are described. Methods and kits for ascertaining the presence of one or more mutant EGFr, mutant PI3K, and/or mutant B-Raf in a sample and for treating disorders or conditions related to the presence of mutant EGFr, mutant PI3K, and/or mutant B-Raf are also described. Methods of treating tumors containing mutant EGFr, mutant PI3K, and/or mutant B-Raf are also described.

L'invention concerne des mutations du récepteur de facteur de croissance épidermique (EGFr), de phosphatidylinositol 3'-kinase ("PI3K"), et de B-Raf. L'invention concerne également des procédés de traitement des tumeurs contenant l'EGFr muté avec des anticorps monoclonaux humains contre l'EGFr. Elle concerne aussi des procédés et des nécessaires destinés à assurer la présence d'un ou plusieurs EGFr mutants, PI3K mutants ou B-Raf mutants dans un échantillon et en vue de traiter des troubles ou des conditions relatives à la présence de l'EGFr mutant, PI3K mutant et/ou B-Raf mutant. L'invention concerne enfin des procédés de traitement de tumeurs contenant l'EGFr mutant, PI3K mutant et/ou B-Raf mutant.

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