Epigenetic regulatory complex for control of gene expression

Details Epigenetic regulatory complex for control of gene expression Epigenetic regulatory complex for control of gene expression

C - Chemistry, Metallurgy

12

N

C12N 9/10 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2686559

An epigenetic regulatory polypeptide complex comprises at least a first domain having site-specific DNA binding activity and at least a second domain having an arginine methyltransferase activity, wherein the second domain is capable of methylating an arginine residue located in the tail region of a histone H2A. The complex is able to regulate gene expression in cells, particularly in mammalian stem cells by controlling the methylation of R3 in the tail regions of histones H2A and H4. The complex is exemplified by a polypeptide complex comprising the DNA binding activity of Blimpi and the arginine methyltransferase activity of Prmt5.

La présente invention concerne un complexe polypeptidique régulateur épigénétique comportant au moins un premier domaine présentant une activité de liaison à l'ADN spécifique de site et au moins un second domaine ayant une activité méthyltransférase de l'arginine, ledit second domaine étant capable de méthylation d'un résidu d'arginine se trouvant dans la région de queue d'un histone H2A. Le complexe est capable de réguler l'expression génique dans des cellules, notamment dans des cellules souches mammaliennes en contrôlant la méthylation de R3 dans les régions de queue des histones H2A et H4. Le complexe est matérialisé par un complexe polypeptidique présentant l'activité de liaison à l'ADN de Blimp1 et l'activité méthyltransférase d'arginine de Prmt5.

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