C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2404568
There is disclosed a diagnostic or prognostic assay for cancer, particularly gastrointestinal and esophageal adenocarcinoma. Specifically, the present invention provides a methylation pattern that can be assayed by standard methylation assays of CpG islands, including which genes are hypermethylated and which genes are unmethylated in gastrointestinal and esophageal adenocarcinomas, Barrett's esophagous, and normal squamous mucosa.
L'invention concerne une analyse diagnostique ou prognostique du cancer, notamment des adénocarcinomes gastro-intestinaux et oesophagiens. Plus spécialement, l'invention concerne un schéma de méthylation pouvant être analysé par des analyses de méthylation traditionnelles d'îlots CpG, dont les gènes sont hyperméthylés et déméthylés dans des adénocarcinomes gastro-intestinaux et oesophagiens, l'oesophage de Barrett et la muqueuse squameuse normale.
Eads Cindy
Laird Peter
Smart & Biggar
University Of Southern California
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