Epimerization of malonic acid esters

C - Chemistry – Metallurgy – 07 – D

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260/244.2

C07D 498/04 (2006.01) C07D 505/00 (2006.01)

Patent

CA 1192193

- Abstract - A compound represented by the formula (II) epimerizes by the action of a base and the product is precipitated for shifting the equiliblium to yield the corresponding epimer represented by the formula (I). Image Image (II) (I) wherein Ar is an optionally substituted aryl or heterocyclic group; Tet is an optionally substituted tetrazolyl group and B1 and B2 are each ester forming group in the field of penicillin or cephalosporin chemistry. - 1 -

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