C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/00 (2006.01) A61K 31/726 (2006.01) A61K 31/727 (2006.01) A61K 31/737 (2006.01) C07H 1/00 (2006.01) C08B 37/08 (2006.01) C08B 37/10 (2006.01)
Patent
CA 2489862
A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives.
L'invention porte sur un nouveau procédé de sursulfatation de l'épiK5-N-sulfate pour obtenir de l'épiK5-amine-O-sursulfate à très fort degré de sulfatation, qui par une N-sulfatation subséquente donne de nouveaux dérivés d'épiK5-N,O-sursulfate, présentant un degré de sulfatation d'au moins 4, pratiquement exempt d'activité sur les paramètres de coagulation, et s'avérant utile dans les domaines cosmétiques et pharmaceutiques. L'invention porte également sur des épiK5-N-sulfates utiles comme intermédiaires dans la préparation de dérivés correspondants de LMW épiK5-N,O-sursulfate.
Oreste Pasqua Anna
Zoppetti Giorgio
Glycores 2000 S.r.l.
Robic
LandOfFree
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