Epimers of...

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C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2199273

The present invention relates to the epimers: (22R)-N-(1,1,1-trifluoro-2- phenylprop-2-yl)-3-oxo-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide and (22S)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide useful as inhibitors of testosterone 5.alpha.-reductase enzyme, to a process for their preparation and to pharmaceutical compositions containing them.

L'invention concerne les épimères (22R)-N-(1,1,1-trifluoro-2-phénylprop-2-yl)-3-oxo-4-aza-5.alpha.-androst-1-ène-17.beta.-carboxamide et (22S)-N-(1,1,1-trifluoro-2-phénylprop-2-yl)-3-oxo-4-aza-5.alpha.-androst-1-ène-17.beta.-carboxamide, servant d'inhibiteurs de la testostérone 5.alpha.-réductase. L'invention concerne également un procédé pour leur préparation et les compositions pharmaceutiques les contenant.

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