Epimorphian compound and its use

Details Epimorphian compound and its use Epimorphian compound and its use

A - Human Necessities

61

K

A61K 31/435 (2006.01) C07D 221/28 (2006.01) C12Q 1/00 (2006.01) G01N 30/02 (2006.01) G01N 30/88 (2006.01)

Patent

CA 2318959

A novel compound N-demethyl-sinomenine, a metabolite of the anti-arthritic alkaloid sinomenine, has been identified and characterized. The compound may be incorporated in a pharmaceutical composition and may be administered to patients for treatment of various disorders, such as rheumatoid arthritis. The novel compound has superior biological activity and water solubility as compared to sinomenine.

On a identifié et caractérisé un nouveau composé, le N-diméthyl-sinoménine, qui est un métabolite de la sinoménine alcaloïdique anti-arthritique. Le composé peut être incorporé dans une composition pharmaceutique et peut être administré à des patients pour traiter diverses pathologies, telles que la polyarthrite rhumatoïde. Le nouveau composé se caractérise par une meilleure activité biologique et une meilleure solubilité dans l'eau que la sinoménine.

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