Epinine esters, method for their preparation and related...

Details Epinine esters, method for their preparation and related... Epinine esters, method for their preparation and related...

C - Chemistry, Metallurgy

07

C

260/489.7

C07C 217/00 (2006.01) A61K 31/21 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/24 (2006.01) C07C 211/00 (2006.01)

Patent

CA 1113117

ABSTRACT OF THE DISCLOSURE . - Novel cardiocirculatory analeptics are prepared, which are epinine esters as obtained by reacting epinine (N-methyldopamine) with branched- chain aliphatic carboxylic acids. Exemplary members are 3,4-di-O-butyrylepinine and 3,4-di-O-pivaloylepinine. These medicaments are effective also by the oral route of administration, contrary to the hitherto commonly used dopamine derivatives which are rapidly destroyed by metabolization when administered orally.

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