Epipodophyllotoxin triaryloxyacetyl derivatives, method for...

C - Chemistry – Metallurgy – 07 – H

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C07H 15/26 (2006.01) A61K 31/70 (2006.01) C07H 17/04 (2006.01)

Patent

CA 2212956

Derivatives of general formula (I), wherein R' is methyl or 2-thienyl, R is an acyl group of formula R1OCH2CO, wherein R1 is a phenyl ring ortho-, meta- or para-substituted by one or more substituents X, where X is a formyl, acetyl, cyano or trifluoroacetyl group, and pharmaceutically acceptable salts thereof, are disclosed. A method for preparing said derivatives, their use as a drug, and pharmaceutical compositions containing them, are also disclosed.

La présente invention a pour objet les dérivés de formule générale (I), dans laquelle R' représente un méthyle ou un 2-thiényle, R représente un groupe acyle de formule R1OCH2CO, dans laquelle R1 est un noyau phényle substitué par un ou plusieurs substituants X, en position ortho, meta ou para, X représentant un groupe formyle, acétyle, cyano ou trifluoro acétyle, et leurs sels pharmaceutiquement acceptables. La présente invention concerne également leur procédé de préparation, leur utilisation à titre de médicament et les compositions pharmaceutiques les comprenant.

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