Episomal fusion gene

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07K 14/82 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) C12N 15/54 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2564784

The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

La présente invention se rapporte à une structure épisomique exprimant un oncogène fonctionnel, ledit oncogène étant un gène de fusion de deux fragments de gène chromosomique. Plus précisément, l'invention a trait à un produit de fusion NUP214-ABL1, qui joue un rôle important dans le développement de la leucémie aiguë lymphoblastique T, à des procédés permettant de détecter la fusion, et à des procédés permettant d'inhiber l'activité oncogène dudit produit de fusion.

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