Epithelial adhesive lactobacilli

A - Human Necessities – 61 – K

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A61K 35/74 (2006.01) A61P 13/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2216150

The invention refers to the use of Lactobacillus plan- tarum having a mannose-specific adhesin for the prepara- tion of a pharmaceutical composition inhibiting the bind- ing of pathogenic bacteria expressing mannose-specific ad- hesins to the epithelial cell surface. A strain of Lactobacil- lus plantarum which can be used in the invention adheres to D-mannose-coated agarose beads, and preferably belongs to a cluster of L. plantarum with more than 70 % similar- ity to L. plantarum 299 in terms of REA. The invention also refers to the use of said strains for the preparation of a phar- maceutical composition to be used in prophylatic and/or curative treatment of bacterial translocation, gastroenteritis and other diseases caused by pathogenic bacteria express- ing mannose-specific adhesins.

Utilisation de Lactobacillus plantarum présentant une adhésine spécifique au mannose pour la préparation d'une composition pharmaceutique inhibant la liaison de bactéries pathogènes exprimant des adhésines spécifiques au mannose à la surface des cellules épithéliales. Une souche de Lactobacillus plantarum pouvant être utilisée dans l'invention adhère à des perles d'agarose enrobées de D-mannose, et appartient de préférence à un groupe de L. Plantarum présentant plus de 70 % de similitude avec L. plantarum 299 d'après un test REA. L'invention concerne également l'utilisation de ces souches pour la préparation d'une composition pharmaceutique à utiliser comme traitement prophylactique et/ou curatif de migrations bactériennes, de la gastro-entérite et d'autres maladies provoquées par des bactéries pathogènes exprimant des adhésines spécifiques au mannose.

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