C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 7/06 (2006.01) C07K 14/705 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2554001
A peptide comprising the amino acid sequence represented by SEQ ID NO:1; a peptide comprising the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide comprising an amino acid sequence derived from an amino acid sequence represented by SEQ ID NO:1 or 2 by addition, deletion or substitution of one or more amino acids and being capable of forming a complex with an HLA- A2402 molecule that can be recognized by HLA-A2402-restricted cytotoxic T lymphocytes or being capable of inducing the same. Such a peptide is useful as a cancer vaccine for epithelial cancer patients having HLA-A2402.
L'invention concerne un peptide contenant la séquence d'acides aminés représentée par SEQ ID NO:1, un peptide contenant la séquence d'acides aminés représentée par SEQ ID NO:2; ou un peptide mutant contenant une séquence d'acides aminés dérivée d'une séquence d'acides aminés représentée par SEQ ID NO:1 ou 2 par addition, délétion ou substitution d'un ou de plusieurs acides aminés, et étant capable de former un complexe avec une molécule HLA-A2402 pouvant être reconnue par les lymphocytes T cytotoxiques à restriction HLA-A2402 ou étant capable de l'induire. Ledit peptide est utile en tant que vaccin anticancéreux chez des patients atteints d'un cancer épithélial présentant un HLA-A2402.
Aichi Prefecture
Marks & Clerk
Otsuka Pharmaceutical Co. Ltd.
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