C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/10 (2006.01) A61K 39/09 (2006.01) C07K 7/08 (2006.01) C07K 14/315 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2326408
The invention provides a nucleic acid encoding the 37-kDa pneumococcal surface adhesion A protein (PsaA) from Streptococcus pneumoniae. Also provided are isolated nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention also provides purified polypeptides encoded by the nucleic acid encoding the 37-kDa protein from and the nucleic acids comprising a unique fragment of at least 10 nucleotides of the 37-kDa protein. The invention further provides monoclonal antibodies which selectively bind PsaA. In addition peptides are provide that immunospecifically bind to the monoclonal antibodies of the invention, and that are immunogenic against Streptococcus pneumoniae infection. Also provided are vaccines comprising such immunogenic polypeptides, and methods of conferring protective immunity against Streptococcus pneumoniae infection by administering therapeutic compositions comprising the immunogenic peptides of the invention. Also provided are methods of detecting the presence of Streptococcus pneumoniae in a sample using antibodies or antigens, and methods of preventing and treating Streptococcus pneumoniae infection in a subject. In addition a method of identifying the sequence of a peptide potentially capable of eliciting protective immunity against a pathogenic microorganism is provided.
L'invention concerne un acide nucléique codant la protéine A d'adhésion à la surface pneumococcique 37-kDa (PsaA) à partir de Streptococcus pneumoniae. On décrit des acides nucléiques comprenant un fragment unique d'au moins 10 nucléotides de la protéine 37-kDa, ainsi que des polypeptides purifiés codés par l'acide nucléique codant la protéine 37-kDa à partir d'acides nucléiques comprenant un fragment unique d'au moins 10 nucléotides de la protéine 37-kDa. On décrit des anticorps monoclonaux qui lient sélectivement PsaA. On décrit également des peptides immunogènes contre l'infection par Streptococcus pneumoniae, qui se lient de manière immunospécifique aux anticorps monoclonaux de l'invention. L'invention concerne également des vaccins comprenant lesdits peptides immunogènes, et des procédés pouvant conférer une immunité protectrice contre l'infection par Streptococcus pneumoniae, par administration de compositions thérapeutiques contenant les peptides immunogènes de l'invention. L'invention concerne en outre des procédés mettant en oeuvre des anticorps et des antigènes pour détecter la présence de Streptococcus pneumoniae dans un échantillon, ainsi que des méthodes de prévention ou de traitement de l'infection par Streptococcus pneumoniae chez un sujet. L'invention concerne enfin un procédé permettant d'identifier la séquence d'un peptide pouvant éliciter une immunité protectrice contre un micro-organisme pathogène.
Ades Edwin W.
Carlone George M.
Sampson Jacquelyn S.
Tharpe Jean A.
Westerink Maria Anna Julia
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Macrae & Co.
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