Epitope synchronization in antigen presenting cells

Details Epitope synchronization in antigen presenting cells Epitope synchronization in antigen presenting cells

C - Chemistry, Metallurgy

07

K

C07K 14/74 (2006.01) C12N 5/0783 (2010.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) C12Q 1/37 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2405363

Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.

. La présente invention concerne des vaccins et des procédés permettant d'induire une réponse immunitaire contre des cellules cancéreuses et des cellules infectées par des parasites intracellulaires. L'invention concerne également des vaccins ayant des épitopes constitutifs. L'épitope constitutif est constitué de protéasomes constitutifs dans des cellules périphériques, mais non pas par des cellules professionnelles présentant des antigènes. Ainsi, un vaccin contenant un épitope constitutif dérivé d'un antigène associé à une cellule périphérique cible peut diriger une réponse immunitaire contre la cellule cible. L'invention concerne également des procédés de traitement comportant l'administration d'un vaccin comprenant un épitope constitutif.

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