Epitopes formed by non-covalent association of conjugates

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) C07K 1/107 (2006.01) C07K 5/06 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2377783

A composition for interacting with a ligand, which composition comprises a non- covalent association of a plurality of distinct conjugates, each conjugate comprising a head group and a tail group, wherein the tail groups of the conjugates form a hydrophobic aggregation and the conjugates are movable within the association so that, in the presence of a ligand, at least two of the head groups are appropriately positioned to form an epitope capable of interacting with the ligand more strongly than each of head groups individually.

La présente invention concerne une composition destinée à interagir avec un ligand. Cette composition comprend une association non covalente de plusieurs conjugués distincts, chaque conjugué comprenant un groupe de tête et un groupe de queue. Les groupes de queue des conjugués forment un agrégat hydrophobe et les conjugués peuvent se déplacer au sein de l'association de façon que, en présence d'un ligand, au moins deux des groupes de tête sont positionnés de manière adéquate, afin de former un épitope capable d'interagir avec le ligand plus fortement que chacun des groupes de tête individuellement.

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