C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 37/08 (2006.01) C07K 16/42 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2363637
The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are isolated peptides incorporating epitopes or mimotopes of surface exposed regions of the C.epsilon.2 domain of IgE. The inventors have found that these novel regions may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the surface exposed IgE regions of the present invention, and their use in medicine as passive immunotherapy or in immunoprophylaxis.
La présente invention concerne de nouveaux médicaments destinés au traitement, à la prévention ou à l'atténuation des allergies. Ces nouveaux médicaments sont notamment des peptides isolés comprenant des épitopes ou des mimotopes des régions exposées en surface du domaine C.epsilon.2 des IgE. Les inventeurs ont découvert que ces nouvelles régions peuvent servir de cible à l'immunoprophylaxie ou à l'immunothérapie, active ou passive. L'invention concerne également des procédés de préparation de médicaments, de compositions pharmaceutiques les contenant et leur utilisation en médecine. L'un des aspects de la présente invention couvre des ligands, notamment des anticorps monoclonaux, qui sont capables de lier les régions exposées en surface des IgE de la présente invention, et leur utilisation en médecine et en immunoprophylaxie ou en immunothérapie passive.
Dyson Michael
Friede Martin
Greenwood Judith
Hewitt Ellen
Lamont Alan
Borden Ladner Gervais Llp
Peptide Therapeutics Limited
Smithkline Beecham Biologicals S.a.
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