Epothilone derivatives

Details Epothilone derivatives Epothilone derivatives

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01) C07D 405/06 (2006.01) C07D 407/06 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2494259

This invention relates Epothilone derivatives of formula (I), wherein the symbols and substituents are as defined in the description, to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives , for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

La présente invention concerne des dérivés d'Epothilone représentés par la formule générale (I) dans laquelle les symboles et les substituants sont définis dans la partie descriptive de la présente demande. L'invention concerne également des procédés servant à la préparation de ces dérivés, des compositions pharmaceutiques contenant ces dérivés et l'utilisation de ces dérivés pour la préparation de compositions pharmaceutiques destinées en particulier au traitement d'une maladie proliférative, telle qu'une tumeur.

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