Epoxide inhibitors of cysteine proteases

Details Epoxide inhibitors of cysteine proteases Epoxide inhibitors of cysteine proteases

C - Chemistry, Metallurgy

07

D

C07D 303/48 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2655139

Provided herein are novel epoxide inhibitors of cysteine proteases, compositions comprising the epoxide inhibitors, and packaged pharmaceuticals. Also provided are methods of inhibiting a papain-family cysteine protease and methods of treating or preventing a disease by administering a composition containing an epoxide inhibitor of the invention. The compositions may be administered in combination with another therapeutic agent.

La présente invention concerne de nouveaux inhibiteurs époxyde de cystéine protéases, des compositions contenant ces inhibiteurs époxyde, et des produits pharmaceutiques conditionnés. L'invention concerne également des procédés d'inhibition d'une cystéine protéase appartenant à la famille de la papaïne et des procédés de traitement ou de prévention d'une maladie grâce à l'administration d'une composition contenant un inhibiteur époxyde selon l'invention. Les compositions peuvent être administrées sous forme combinée à un autre agent thérapeutique.

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