Epoxide intermediate in the tamiflu synthesis

Details Epoxide intermediate in the tamiflu synthesis Epoxide intermediate in the tamiflu synthesis

C - Chemistry, Metallurgy

07

C

C07C 67/08 (2006.01) C07C 69/757 (2006.01) C07C 309/66 (2006.01) C07D 301/02 (2006.01) C07D 303/40 (2006.01) C07D 317/48 (2006.01)

Patent

CA 2633538

The present invention relates to technology for preparing derivatives of unsaturated, cyclic, organic acids and salts, thereof. Shikimic acid is an example of such an acid. More particularly, the present invention relates to preparing derivatives of these acids or salts thereof that are esterified, ketalized, functionalized with a leaving group, and/or provided with epoxide functionality. Preferred aspects may be used in the synthesis of Oseltamivir Phosphate starting from shikimic acid.

La présente invention concerne une technologie pour préparer des dérivés d'acides organiques cycliques insaturés et leurs sels. L'acide shikimique est un exemple d'un tel acide. Plus particulièrement, la présente invention concerne la préparation de dérivés d'acides ou de leurs sels qui sont estérifiés, acétalisés, fonctionnalisés avec un groupe partant, et/ou présentant une fonctionnalité époxy. Les aspects préférés peuvent être utilisés dans la synthèse du phosphate d'oseltamivir à partir de l'acide shikimique.

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