Eprosartan compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/46 (2006.01) A61K 31/4178 (2006.01) A61K 31/549 (2006.01) A61P 9/04 (2006.01) A61P 9/12 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2730008

The disclosed invention relates to a method of treatment of a disorder modulated by blocking angiotensin I1 (All) receptors, and particularly selected from the group consisting of hypertension, congestive heart failure, renal failure, and combinations thereof, by administering to a subject in need thereof an effective dose of an eprosartan compound. With reference to the Recommended Effective Daily Dose of 600 mg, calculated on the basis of eprosartan administered in the form of eprosartan mesylate, it has now been found that a lower dose of eprosartan can be administered when the eprosartan compound is eprosartan acid. This dose is in the range of from 410 to 490 mg, most preferably about 450 mg.

La présente invention porte sur un procédé de traitement d'un trouble modulé par le blocage des récepteurs de l'angiotensine II (AII) et, en particulier, choisi dans le groupe constitué par l'hypertension, une insuffisance cardiaque congestive, une insuffisance rénale et des combinaisons correspondantes, par l'administration à un sujet en ayant besoin d'une dose efficace d'un composé d'éprosartan. En faisant référence à la dose quotidienne efficace recommandée de 600 mg, calculée sur la base de l'éprosartan administré sous la forme de mésylate d'éprosartan, il a maintenant été établi quil est possible dadministrer une dose inférieure d'éprosartan lorsque le composé d'éprosartan est de l'acide d'éprosartan. Cette dose se situe dans la plage de 410 à 490 mg, idéalement à environ 450 mg.

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