C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/06 (2006.01) A61K 31/4178 (2006.01) A61K 31/44 (2006.01) A61K 31/54 (2006.01) A61K 31/635 (2006.01) A61K 38/55 (2006.01)
Patent
CA 2294515
This invention relates to (E)-.alpha.-[2-n-butyl-1-[(4-carboxyphenyl)methyl]- 1H-imidazol-5-yl]methylene-2-thiophenepropionic acid monomethanesulfonate monohydrate, compositions containing the compound and methods of using the compound to block angiotensin II receptors and to treat hypertension, congestive heart failure and renal failure.
Cette invention concerne un monométhanesulfonate monohydrate d'acide (E)- alpha -[2-n-butyl-1-[(4-carboxyphényl)méthyl]-1H-imidazol-5-yl]méthylène-2-thiophènepropionique, des compostions contenant ce composé ainsi que des procédés d'utilisation de ce composé pour bloquer les récepteurs de l'angiotensine II et traiter l'hypertension, l'insuffisance cardiaque globale et l'insuffisance rénale.
Duddu Sarma
Palepu Nageswara R.
Venkatesh Gopadi M.
Glaxosmithkline Llc
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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