A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/40 (2006.01) A61F 2/06 (2006.01) A61L 27/54 (2006.01) A61L 27/56 (2006.01) A61F 2/00 (2006.01)
Patent
CA 2465704
An implantable composite device for regulated delivery of bioactive agents to the site of implantation includes at least two zones of distinct porosities through its cross-section. One zone is of a sufficient porosity to permit regulated transport of bioactive agents associated with the device to an area of the body in need of treatment. The bioactive agent associated with the device an be either a therapeutic or diagnostic agent. In a particular embodiment of the invention, the device includes a tubular body consisting of a first luminal layer of ePTFE a porosity sufficient to promote cell endothelization along the luminal surface; and a second polymeric layer disposed on the first layer of a porosity permitting regulated transport of the bioactive agents.
L'invention concerne un dispositif composite implantable permettant de réguler l'administration de principes bioactifs au site d'implantation, qui comprend au moins deux zones de porosité différente sur sa section transversale. La porosité d'une zone est suffisante pour réguler le transport de principes bioactifs associés au dispositif vers une région du corps à traiter. Le principe bioactif associé au dispositif peut être un agent thérapeutique ou diagnostique. Selon une variante spécifique, le dispositif comprend un corps tubulaire ayant une première couche luminale de PTFE expansé dont la porosité est suffisante pour favoriser l'endothélialisation cellulaire le long de la surface luminale, et une seconde couche polymère disposée le long de la première couche, dont la porosité permet de réguler le transport de principes bioactifs.
Hill Jason Peter
Sogard David John
Tseng David
Boston Scientific Limited
Kirby Eades Gale Baker
LandOfFree
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