Equine fc epsilon receptor alpha chain nucleic acid...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/735 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2319310

The present invention relates to equine Fc epsilon receptor alpha chain nucleic acid molecules, proteins encoded by such nucleic acid molecules, antibodies raised against such proteins, and inhibitors of such proteins. The present invention also includes methods to detect IgE using such proteins and antibodies. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to mediate Fc epsilon receptor-mediated biological responses.

La présente invention concerne des molécules d'acides nucléiques de la chaîne .alpha. du récepteur Fc.epsilon. équin, des protéines codées par de telles molécules d'acides nucléiques, des anticorps dirigés contre de telles protéines, et des inhibiteurs de telles protéines. L'invention concerne également des procédés visant à la détection de l'IgE par utilisation de telles protéines et de tels anticorps. L'invention concerne en outre des compositions thérapeutiques comprenant de telles protéines, de telles molécules d'acide nucléique, des anticorps et/ou des composés inhibiteurs, ainsi que l'utilisation de telles compositions thérapeutiques comme médiateur pour les réponses biologiques à médiation du récepteur de Fc.epsilon..

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