Equine herpesvirus vaccine

Details Equine herpesvirus vaccine Equine herpesvirus vaccine

A - Human Necessities

61

K

A61K 39/27 (2006.01) A61K 39/145 (2006.01) A61K 39/245 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01)

Patent

CA 2441292

A vaccine for protecting a horse against diseases associated with EHV-1 and/or EHV-4 is provided. The vaccine commonly includes inactivated EHV-1 (e.g., chemically inactivated EHV-1 KyA virus), using ethylenimine and an adjuvant. The adjuvant can include a cross-linked olefinically unsaturated carboxylic acid polymer which may have bioadhesive properties. The vaccine may also include antigens against other equine pathogens such as inactivated EHV-4 and inactivated A1 and/or A2 strains of equine influenza virus. Methods for protecting horses against diseases associated with EHV-1 and/or EHV-4 and methods of producing the equine herpesvirus vaccine are also provided.

L'invention concerne un vaccin destiné à protéger un cheval contre des maladies associées au virus EHV-1 et/ou EHV-4. Ce vaccin comprend normalement un EHV-1 (virus EHV-1 KyA à inactivation chimique, par exemple) ainsi qu'un adjuvant. L'adjuvant peut renfermer un polymère d'acide carboxylique réticulé à insaturation oléfinique pouvant présenter des propriétés bioadhésives. Ce vaccin peut également comprendre des antigènes dirigés contre d'autres agents pathogènes, tels qu'un EHV-4 inactivé et des souches A1 et/ou A2 inactivées du virus de la grippe équine. L'invention concerne en outre des méthodes destinées à protéger les chevaux contre les maladies associées à EHV-1 et/ou EHV-4, ainsi que des méthodes de production du vaccin contre le virus herpétique équin.

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