Equine influenza virus and its cultivation

Details Equine influenza virus and its cultivation Equine influenza virus and its cultivation

C - Chemistry, Metallurgy

12

N

167/130, 195/1.2

C12N 7/00 (2006.01) A61K 39/145 (2006.01)

Patent

CA 1261772

Abstract It is known that the human influenza virus strain A/Puerto Rico/8/34 grows particularly well in eggs and that reassorted viruses having it as a parent may also grow well in eggs. It has now been found that certain reassortants of A/PR/8/34 and equine influenza viruses, namely those which comprise the RNA7 segment from A/PR/8/34, will grow in cell culture, even though the parent equine influenza virus will not. Thus the specification describes and claims: reassorted viruses comprising genes for surface antigens of equine influenza viruses and the RNA7 segment from A/PR/8/34; methods of obtaining such viruses by reassortment; methods of propagating such reassorted viruses in cell culture, especially Vero cells; vaccines against equine influenza comprising such reassorted viruses; and methods of vaccinating equines against influenza.

444864

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