C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/20 (2006.01) A61K 39/395 (2006.01) C07K 16/32 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2246429
Antibodies are disclosed which bind to ErbB3 protein and further possess any one or more of the following properties: an ability to reduce heregulin-induced formation of an ErbB2-ErbB3 protein complex in a cell which expresses ErbB2 and ErbB3; the ability to increase the binding affinity of heregulin for ErbB3 protein, and the characteristic of reducing heregulin-induced ErbB2 activation in a cell which expresses ErbB2 and ErbB3.
L'invention a trait à des anticorps se fixant à la protéine ErbB3 et qui possèdent, en outre, l'une des propriétés suivantes ou davantage: aptitude à réduire la formation, induite par l'héréguline, d'un complexe protéique ErbB2-ErbB3 dans une cellule qui exprime les protéines ErbB2 et ErbB3, aptitude à accroître l'affinité de fixation de l'héréguline pour la protéine ErbB3 et pouvoir de réduire l'activation de la protéine ErbB2 induite par l'héréguline dans une cellule qui exprime les protéines ErbB2 et ErbB3.
Akita Robert
Sliwkowski Mark
Dennison Associates
Genentech Inc.
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