C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2296807
The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.
L'invention concerne un nouveau ligand associé à une neuréguline (NRG3) y compris ses fragments et variants comme nouveaux membres de la famille de composés de neuréguline. L'invention concerne également des méthodes et moyens de production de NRG3. Les polypeptides endogènes de l'invention se caractérisent par le fait qu'ils contiennent un domaine extracellulaire comprenant un domaine analogue d'EGF, un domaine transmembranaire et un domaine cytoplasmique. L'invention concerne en outre des séquences nucléotidiques isolées codant ces polypeptides, des vecteurs d'expression contenant les séquences nucléotidiques, des cellules hôtes de recombinaison transformées par les vecteurs, ainsi que des méthodes de production par recombinaison des nouveaux NRG3.
Godowski Paul J.
Mark Melanie R.
Zhang Dong-Xiao
Dennison Associates
Genentech Inc.
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