Ergoline derivatives, process for the preparation thereof,...

Details Ergoline derivatives, process for the preparation thereof,... Ergoline derivatives, process for the preparation thereof,...

C - Chemistry, Metallurgy

07

D

260/206

C07D 457/12 (2006.01)

Patent

CA 1253488

ABSTRACT OF THE DISCLOSURE Substituted ergolines of the formula Image (I) and their acid addition salts, wherein the urea side chain in the 8-position can be in the .alpha.- or .beta.-configuration, C2----C3 and C9----C10 are a CC single or C=C double bond, and R is hydrogen or NR'R'' wherein R'R'' is O2, H2, C1-4- dialkyl, or, together, they form a 3- to 9-membered ring, or R' and R'' individually are hydrogen, C1-4-alkyl, or C1-10- acyl, R1 is hydrogen, C1-4-alkyl, C1-10-acyl, C6-8-aryl, or C1-4-alkylsulfonyl, R2 is hydrogen or halogen if C2----C3 is a C=C double bond, or hydrogen if C2----C3 is a CC single bond, R6 is C1-4-alkyl, provided that R, R1 and R2 are not all hydrogen and when R and R2 are hydrogen and C2----C3, and C9----C10 are double bonds R1 is other than methyl, show a pronounced effect on the central nervous system and are suitable, for example, as antidepressants, neuroleptics, or antihypertensives.

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