Ergoline derivatives, their production and pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

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260/206.7

C07D 457/02 (2006.01)

Patent

CA 1178582

100-5555 Abstract A compound of formula I Image I in which R1 is H,(C1-4)alkyl or a precursor thereof, R2 is (C1-4)alkyl, R3 and R4 independently are H, (C1-4)alkyl or together (C2-5)- alkylene, R5 is H or alkyl, and A and B each are H or both together are a bond with the proviso that, when R1 and R2 are each CH3,R3 and R4 are each C2H5 and A and B are each H, then R5 is alkyl in free base form or in pharmaceutically acceptable acid addition salt form. The compounds are used in the treatment of hypertension and cardiac insufficiency. 3700/KD/MR

396775

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