Ergolinyl heterocycles

Details Ergolinyl heterocycles Ergolinyl heterocycles

C - Chemistry, Metallurgy

07

D

167/211, 260/206

C07D 457/00 (2006.01) A61K 31/48 (2006.01) A61K 31/505 (2006.01) C07D 457/02 (2006.01)

Patent

CA 1287624

ABSTRACT ERGOLINYL HETEROCYCLES Ergoline derivatives of the formula I Image I wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrogen atom or a methoxy group; R3 represents a hydrocarbon group having from 1 to 4 carbon atoms; X represents a nitrogen atom and Y represents an oxygen atom, a -?-R4 or a -N=?-R5 group wherein R4 represents a hydrogen atom, a C1-C4 alkyl or a phenyl group, R5 represents a hydrogen atom, a C1-C4 alkyl, a phenyl, an amino or di(C1-C4 alkyl)amino group and the nitrogen atom of the group -N=?-R5 is not joined to the nitrogen atom represented by X, or Y represents a nitrogen atom and X represents an oxygen atom or a -?-R4 group wherein R4 is as above defined; and the pharmaceutically acceptable salt thereof; are useful for treatment of Parkinsonism and dyskinetic syndromes.

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