C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C07H 21/04 (2006.01) C12N 15/54 (2006.01)
Patent
CA 2529559
The present invention is directed in part to the discovery of a novel signal transduction pathway that regulates estrogen responsiveness. Human extracellular signal-regulated kinase 8 (ERK8) has been discovered by applicants to preferentially enhance the destruction of ER.alpha. , and loss of ERK8 is correlated with breast cancer progression. Thus monitoring the expression of ERK8 can be used as a diagnostic and therapeutic indicator of cancer and cancer progression.
L'invention concerne en partie la découverte d'un nouvelle voie de transduction de signal régulant la faculté de réponse d'oestrogène. On a découvert que la kinase 8 humaine à régulation de signal extracellulaire (ERK8) augmentait préférentiellement la destruction de ER.alpha., et que la perte de ERK8 était en corrélation avec le développement du cancer du sein. Ainsi, le contrôle de l'expression de ERK8 peut être utilisé comme indicateur de diagnostic et comme thérapeutique du cancer et du développement du cancer.
Henrich Lorin M.
Lannigan-Macara Deborah A.
Smith Jeffrey A.
Gowling Lafleur Henderson Llp
University Of Virginia Patent Foundation
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