C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/10 (2006.01) A61K 31/66 (2006.01) C07F 9/09 (2006.01) C07F 9/113 (2006.01) C07F 9/173 (2006.01) C07F 9/572 (2006.01) C07F 9/59 (2006.01) C07F 9/6533 (2006.01) C07F 9/655 (2006.01)
Patent
CA 2065104
New erucyl, brassidyl and nervonyl derivatives The present invention provides compounds of the general formula:- (see formula I) wherein R is a erucyl, brassidyl or nervonyl radical, R1, R2 and R3 are, independently of one mother, straight-chained, branched or cyclic saturated or unsaturated alkyl radicals containing up to 4 carbon atoms, which can also contain a hydroxyl group, and wherein two of these radicals can also be connected to form airing, A is a valency bond or a radical of one of the formulae: (see formula II, III, IV) -CH-CH-CH2-O- (see formula VI) or (CH2-CH2-O- whereby the radicals (II) to (VII) have an orientation such that the oxygen atom is attached to the phosphorus atom of the compound (I), and X is an oxygen atom when A is a valency bond or is an oxygen or sulphur atom when A is one of the radicals (II) to (VII). The present invention also provides a process for the preparation of the compounds of general formula (I) and pharmaceutical compositions so n- taining them which can be used for the treatment of protozoal and fungal diseases, auto-immune diseases and bone marrow damage,
Eibl Hansjorg
Max-Planck-Gesellschaft
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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