Erythro diols

Details Erythro diols Erythro diols

C - Chemistry, Metallurgy

07

C

260/515, 260/542

C07C 59/48 (2006.01) C07C 69/732 (2006.01) C07D 319/04 (2006.01) C07D 407/10 (2006.01)

Patent

CA 1269109

ABSTRACT The invention concerns novel erythro diols of the formula XIII Image XIII having the groups QaOCH2- and QbO in erythro-stereochemical relationship and wherein one of Qa and Qb is hydrogen and the other is hydrogen, alkanesulphonyl and arenesulphonyl; Rc is hydroxy, alkoxy or alkanesulphonamido, n is 1 or 2, A is ethylene or vinylene, Y is (2-5C)polymethylene optionally substituted by alkyl, and benzene ring B is optionally substituted phenyl, or, when Rc is hydroxy, a salt thereof. The erythro diols are useful intermediates in the preparation of 1,3-dioxan-5-ylalkenoic acid derivatives that antagonise one or more of the actions of throm- boxane A2 (TXA2) and are of value in those disease conditions in which TXA2 is involved.

600593

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