Erythrocytes containing arginine deiminase

Details Erythrocytes containing arginine deiminase Erythrocytes containing arginine deiminase

A - Human Necessities

61

K

A61K 38/50 (2006.01) A61P 7/00 (2006.01)

Patent

CA 2606420

Use of erythrocytes containing arginine deirainase for the preparation of a medicinal product for lowering the plasma concentration of arginine in vivo. Said use relates in particular to the treatment of arginine-dependent tumors, such as hepatocarcinoma and malignant melanoma, or inhibition of the synthesis of nitric oxide, and the prevention and/or treatment of septic shock.

On utilise des érythrocytes contenant de l'arginine désiminase pour préparer un produit thérapeutique servant à réduire la concentration plasmatique d'arginine in vivo. Cette utilisation porte notamment sur le traitement des tumeurs dépendant de l'arginine, telles que l'hépatocarcinome et le mélanome malin, ou sur l'inhibition de la synthèse de l'oxyde nitrique, et sur la prévention et/ou le traitement du choc septique.

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