Erythromycin a derivatives

Details Erythromycin a derivatives Erythromycin a derivatives

C - Chemistry, Metallurgy

07

H

C07H 17/00 (2006.01) A61K 31/7048 (2006.01) A61K 31/7056 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01) C07H 17/08 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2343344

The present invention relates to erythromycin A derivatives of the formula: Image and to pharmaceutically acceptable salts, prodrugs, tautomers, and solvates, thereof, wherein X1 is -CO-, -CH(NR5R6)-, -CHR5NR6-, -C(=NR5) - or -C(=NOR5)-; B is O, (CRaaRbb)m, SO2 or NR4; m is 0 or 1; Raa and Rbb are each H or alkyl or together form a ring; R1 is alkyl, aryl or aralkyl; R2 is H, alkyl, or the like; R3 is H, CO-alkyl or the like; R10 is OCONR11R12; R5 and R6 are each H, alkyl or the like or together form a ring; R4 is H, alkyl or the like; R11 is H or alkyl; and R12 is H, alkyl or the like.

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