Erythromycin d and esters thereof by fermentation

Details Erythromycin d and esters thereof by fermentation Erythromycin d and esters thereof by fermentation

C - Chemistry, Metallurgy

12

P

195/89

C12P 19/62 (2006.01) A23K 1/17 (2006.01) C07H 17/08 (2006.01)

Patent

CA 1194439

ERYTHROMYCIN D AND ESTERS THEREOF BY FERMENTATION Abstract Fermentation of a culture of Nocardia sp. ATCC 39043 produces an antibiotic complex comprising eryth- romycin D, 3",4"-di-O-acetylerythromycin D, 3"-O- acetyl-4"-O-propionylerythromycin D and 4"-O-acetyl- erythromycin D. The components are separated and are each useful in vitro and in vivo as antibacterial agents. If erythromycin D is the desired product, the esters can be hydrolyzed prior to the separation of the erythromycin D.

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