Erythromycin derivatives, preparation and use thereof

Details Erythromycin derivatives, preparation and use thereof Erythromycin derivatives, preparation and use thereof

C - Chemistry, Metallurgy

12

P

C12P 19/62 (2006.01) C07H 17/08 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2092045

Disclosed are (1) a structurally novel 6,9-hemiacetal- erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9- hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal- erythromycin derivative or a salt thereof with an organism- derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.

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